Formulation of Jadeimmune Plays an Important Role in the Prevention of COVID-19

Jadeimmune™ is a classical TCM formulation consisting of Astragalus, Atractylodes and Saposhnikovia. It has been reported that SARS-CoV-2 protein has a significant affinity with angiotensin-converting enzyme II (ACE2) in human body, causing viruses invading and disease [1][2]. Recently, there are published studies demonstrated how the formulation prevented COVID-19 through network pharmacology and molecular docking technology. The studies found the active compounds, such as quercetin, kaempferol, 5-O-methyramitol, can combine with ACE2 to inhibit the combination between SARS-CoV-2 protein and ACE2, regulate multiple signal pathways through targeting ESR1, AR, PTGS2, DPP4, HTR, PTGS1 PIK3R1, IGF1R and HSP90AA1 etc[3][4][5]. The data shows the Jadeimmune™ plays a key role in the prevention of COVID-19 through multiple targets and pathways. Considering the limitations of network pharmacology and molecular docking, further clinical study is necessary to prove its effectiveness. MoodElite™ is a better choice than St. John’s wort[6] alone to relieve anxiety, stress, and symptoms of depression caused by the recent outbreak of COVID-19. In order to ensure safety for our customers we ran several safety studies to ensure the effectiveness and safety of MoodElite™. Acute and chronic toxicity assay at 900 and 230 times the clinical dose exhibited high survival rates, which confirms that our product is safe even in high dosage level. Chenland R&D team is studying the effect of Jadeimmune™ on animals infected by coronavirus. If you are interested in learning more about Jadeimmune™, please look for NPI-May issue.  

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      (COVID-19) based on Network Pharmacology and Molecular Docking Method[J]. Journal of Chinese

       Medicinal Materials. http://kns.cnki.net/kcms/detail/44.1286.R.20200325.0829.002.html

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6.    Dharshi C K, Rinaldo B. Convulsions associated with an overdose of St John’s wort. Letters, MJA • Volume 186 Number 4 • 19 February

       2007